Preheat your oven to 325°F (163°C). Grease and flour a 9×5-inch loaf pan or line it with parchment paper for easy removal.

Step 2: Mix the Dry Ingredients

In a medium bowl, whisk together flour, baking powder, baking soda, and salt. Set aside.

Step 3: Cream the Butter and Sugar

In a large mixing bowl, beat the softened butter and sugar together using an electric mixer on medium speed for 3-4 minutes, until light and fluffy.

Step 4: Add the Eggs and Vanilla

Add the eggs one at a time, beating well after each addition. Stir in the vanilla extract until combined.

Step 5: Incorporate the Dry Ingredients and Buttermilk

Gradually add the dry ingredients to the butter mixture, alternating with buttermilk. Begin and end with the dry ingredients. Mix until just combined; do not overmix.

Step 6: Bake the Cake

Pour the batter into the prepared loaf pan and smooth the top. Bake for 60-70 minutes, or until a toothpick inserted into the center comes out clean. If the top browns too quickly, loosely cover with foil during the last 15 minutes of baking.

Step 7: Cool the Cake

Allow the cake to cool in the pan for 10 minutes, then transfer to a wire rack to cool completely before glazing.

Step 8: Prepare the Cream Cheese Glaze

While the cake cools, beat the softened cream cheese until smooth. Gradually mix in powdered sugar, then stir in vanilla extract. Add milk, one tablespoon at a time, until you reach a pourable consistency.

Step 9: Glaze and Serve

Drizzle the cream cheese glaze over the cooled cake, letting it run down the sides. Allow the glaze to set for a few minutes before slicing. Serve and enjoy!