Preheat your smoker to a steady 225°F and grease your loaf pan.

In a mixing bowl, combine ground meat, diced onion, bell pepper, crushed garlic, onion powder, garlic powder, eggs, Worcestershire sauce, half the barbecue sauce, panko and Italian breadcrumbs.

Shape the mixture into a uniform loaf and place it in the prepared pan.

Transfer the meatloaf to the smoker and smoke for approximately 2 hours and 30 minutes until it reaches the proper temperature.

Let the meatloaf rest for 30 minutes on a cutting board.

Glaze with the remaining barbecue sauce before slicing and serving.