Begin by peeling and slicing the large yellow onions into half-inch rounds. In a skillet, heat a tablespoon of olive oil over medium heat, then add the onions along with a splash of Worcestershire sauce. Cook for about 20 minutes, stirring occasionally, until they are golden-brown and fragrant.

While the onions are caramelizing, take the ground beef and mix it with Creole seasoning in a bowl. Use your hands to form the mixture into thin patties, about the size of your caramelized onion rounds. Set the patties aside on a plate, ready for cooking.

In the same skillet as the onions, increase the heat to medium-high and add the seasoned beef patties. Sear them for 2-3 minutes on each side until cooked through. Just before they finish cooking, top each patty with a slice of American cheese.

In a separate bowl, whisk together the mayonnaise, Dijon mustard, relish, garlic powder, onion powder, smoked paprika, and cayenne pepper. Adjust seasoning as desired.

To assemble, start with a caramelized onion round, add a cheesy beef patty, drizzle with sauce, and top with another caramelized onion round.

Serve hot with extra sauce on the side, alongside fries or a fresh salad.