Preheat your oven to 350°F (175°C). Prepare your baking sheet with parchment paper or light greasing.

In a large mixing bowl, combine the ground beef, breadcrumbs, beaten egg, onion, and garlic. Season with salt and pepper and mix well.

Transfer the mixture to the baking sheet and shape it into a loaf about 2 inches high and 6 inches long.

In a separate bowl, whisk together hot sauce, brown sugar, Worcestershire sauce, and ketchup until smooth. Set aside half for basting.

Brush half of the glaze over the top and sides of the meatloaf.

Bake for 45 minutes until firm to touch and slightly browned.

After 45 minutes, apply the remaining glaze and bake for an additional 15 minutes, or until the internal temperature reaches 160°F (70°C).

Remove the meatloaf from the oven and let it rest for about 10 minutes before slicing.